Analysis performed on 2024-09-30 10:30:23
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 48581 | 3541 | 45040 | 26217 |
| Archaea | 3472 | 263 | 3209 | 1409 |
| Vertebrata | 1634 | 654 | 980 | 396 |
| Mammals | 587 | 92 | 495 | 133 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 1262 | 20 | 1082 |
| Domains | |
|---|---|
| Current Study | 1076, 1263 |
| Guo et al (2010) | 1065, 1262 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 1074 | 188 | 1262 | 5.712766 |
| Number of Variants | 943 | 159 | 1102 | 5.930818 |
| Number of Pathogenic Variants | 17 | 3 | 20 | 5.666667 |
| Number of Benign/Unknown Variants | 926 | 156 | 1082 | 5.935897 |
| Fisher exact test | 1.000000 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 1064 | 198 | 1262 | 5.373737 |
| Number of Variants | 940 | 162 | 1102 | 5.802469 |
| Number of Pathogenic Variants | 17 | 3 | 20 | 5.666667 |
| Number of Benign/Unknown Variants | 923 | 159 | 1082 | 5.805031 |
| Fisher exact test | 1.000000 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 1074 | 188 | 0.86 (0.00) | 0.79 (0.01) | 8.790e-01 | 8.279e-01 | 126157.00 | 2.29e-08 |
| Guo et al (2010) | 1064 | 198 | 0.86 (0.00) | 0.79 (0.01) | 8.792e-01 | 8.283e-01 | 131603.00 | 1.21e-08 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.